Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physiological plans and you may pharmacology regarding curcumin
Book ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin is the major component of the new purple dye of turmeric, an Indian liven which is extracted from this new rhizome of your own tropical bush Curcuma longa, and this belongs to the Zingiberaceae nearest and dearest. Contained in this part, i discuss the pharmacological situations from curcumin and mention new molecular angles for these circumstances. I then comment the confirmed and you will possible logical uses out-of curcumin. Curcumin known historically because the a therapeutic agent, but the mechanism out-of action was in depth. Brand new pharmacological outcomes of curcumin appear to be caused by a good synergism from networks regarding poor biochemical relations with multiple physical objectives during the interconnected signaling routes. These plans are enzymes such as for instance cyclooxygenase, lipoxygenase and you can proteins kinases, and you may transcription things particularly NF-?B, STAT and Nrf2. Modulation of those molecules has an effect on downstream affectors which make the antiinflammatory, antioxidant, chemopreventive, anticancer, and you may antimicrobial affairs of curcumin. This type of consequences was looked at within the systematic products of curcumin to have serious pain and you can inflammatory infection, disease, Alzheimer state, cardio illness, and diabetes. The brand new samples have used adjustable doses off curcuminwith other wavelengths and you will cycle, to the general conclusion one large dosages regarding curcumin at the amount of g must receive healing outcomes. Read more
Curcumin: Synthesis, Emerging Character in Discomfort Government and Wellness Effects
Guide Chapter Types of bush-derived pharmaceuticals that have become the appeal off carried on and you will exponential look and invention desire enjoys, up until now, become somewhat scarce. Immediately following many years, the past 20 years was basically characterized by an excellent 100-flex rise in the amount of medical blogs penned per year you to is actually away from importance on the the means to access curcumin in the biomedicine. Read more
Build, synthesis and you will biological factors from curcumin prodrugs
Publication ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin has some potential pharmacological consequences and will possess healing programs in lots of disease says, given that chatted about in more detail in the previous part. However, the potential health-related effectiveness out-of curcumin is bound from the the physicochemical qualities of poor liquid solubility and imbalance, which result in reasonable bioavailability. Prodrugs out-of curcumin give ways to upgrade of one’s biopharmaceutical and you can pharmacokinetic properties, and may even succeed exploitation of your pharmacological results of curcumin. In this part, we first review the latest physicochemical and you can pharmacokinetics out of curcumin. I upcoming describe the design of curcumin prodrugs with increased h2o https://lovingwomen.org/da/guatemalanske-kvinder/ solubility and improved agents balances which are converted back again to 100 % free curcumin on bioactivation during the vivo. We focus on previous success here, that have a focus on the build, synthesis and you can testing out-of prodrugs centered on promoieties in addition to amino acids, fatty acids, nucleic acids, dicarboxylic acids, and polymeric information such as for instance hyaluronic acidic and polyethylene glycol. This section provides the reason for optimisation of your own physicochemical and biopharmaceutical properties together with biological items out-of curcumin prodrugs, to your goal using of those curcumin types from inside the clinical programs. Find out more