Flexeril Side Effects: Frequent Symptoms and Signs

Tizanidine and cyclobenzaprine cause similar side effects. The chart below compares examples of side effects of both drugs. Health insurance plans usually cover the generic forms of both drugs flexeril moa without prior authorization. In many cases, insurance companies will require a prior authorization for Zanaflex or Amrix (a current brand name for extended-release cyclobenzaprine).

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The elderly may also be more at risk for CNS adverse events such as hallucinations and confusion, cardiac events resulting in falls or other sequelae, drug-drug and drug-disease interactions. For these reasons, in the elderly, cyclobenzaprine should be used only if clearly needed. In such patients FLEXERIL should be initiated with a 5 mg dose and titrated slowly upward.

Use with other medical conditions

For most patients, the recommended dose of FLEXERIL is 5 mg three times a day. Based on individual patient response, the dose may be increased to 10 mg three times a day. Use of FLEXERIL for periods longer than two or three weeks is not recommended. Our writers and reviewers are experienced professionals in medicine, addiction treatment, and healthcare.

• The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.
• Health insurance plans usually cover the generic forms of both drugs without prior authorization.
• Other reported side effects of Flexeril include nausea, constipation, blurred vision, unpleasant taste, nervousness, confusion, acid reflux, and abdominal pain or discomfort.
• Regular use of muscle relaxers causes the brain to become used to its effects.

EHealthMe is studying from 36,937 Flexeril users for its effectiveness, alternative drugs and more. Cyclobenzaprine reduced or abolished skeletal muscle hyperactivity in several animal models. Animal studies indicate that cyclobenzaprine does not act at the neuromuscular junction or directly on skeletal muscle. Evidence suggests that the net effect of cyclobenzaprine is a reduction of tonic somatic motor activity, influencing both gamma (γ) and alpha (α) motor systems. In patients with CNS depression, early intubation is advised because of the potential for abrupt deterioration. Seizures should be controlled with benzodiazepines or, if these are ineffective, other anticonvulsants (e.g. phenobarbital, phenytoin).

Before taking cyclobenzaprine,

It may not be safe to breast-feed while using this medicine. If you cannot swallow the capsule whole, you may open the capsule and sprinkle the contents over one tablespoon of applesauce. Rinse the mouth to make sure all of the medicine have been swallowed. Do not take more of it and do not take it more often than your doctor ordered. Do not flush medications down the toilet or pour them into a drain unless instructed to do so.

This weight gain is thought to be attributed to a period of physical inactivity caused by muscle relaxant use. Information on whether long-term use of Flexeril has any impact on weight gain is unknown. However, there is much more clinical research on the effects of cyclobenzaprine for fibromyalgia than tizanidine.

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RxList does not provide medical advice, diagnosis or treatment. You are encouraged to report negative side effects of prescription drugs to the FDA. Cyclobenzaprine HCl relieves skeletal muscle spasm of local origin without interfering with muscle function. It is ineffective in muscle spasm due to central nervous system disease. All patients suspected of an overdose with FLEXERIL should receive gastrointestinal decontamination.

When certain drugs are used with cyclobenzaprine, they may cause more severe side effects such as increased drowsiness or sedation. A person should ask their doctor whether it is safe to combine another medication with cyclobenzaprine and take care not to operate any machinery while taking it. Therefore, when considering the use of cyclobenzaprine while pregnant the necessity for maternal use should be weighed against the benefits of breastfeeding in infants.

Tell your care team if your symptoms do not start to get better or if they get worse. Talk to your care team about the use of this medication in children. Every gift to the Arthritis Foundation will help people with arthritis across the U.S. live their best life. Whether it is supporting cutting-edge research, 24/7 access to one-on-one support, resources and tools for daily living, and more, your gift will be life-changing. There are no adequate studies of Flexeril in pregnant women. Studies in animals suggest no important effects on the fetus.